REDUCED STEROID ACTIVATION OF ELEPHANT SHARK GR AND MR AFTER INSERTING FOUR AMINO ACIDS FROM THE DNA-BINDING DOMAIN OF LAMPREY CORTICOID RECEPTOR-1

Reduced steroid activation of elephant shark GR and MR after inserting four amino acids from the DNA-binding domain of lamprey corticoid receptor-1

Atlantic sea lamprey contains two corticoid receptors (CRs), CR1 and CR2, that have identical amino acid sequences, except for a four Dla Dzieci amino acid insert (Thr-Arg-Gln-Gly) in the CR1 DNA-binding domain (DBD).Steroids are stronger transcriptional activators of CR2 than of CR1 suggesting that the insert reduces the transcriptional response o

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Spirals on the sea

Spiral eddies were first seen Spark Plugs in the sun glitter on the Apollo Mission 30 years ago; they have since been recorded on SAR missions and in the infrared.The spirals are globally distributed, 10-25 km in size and overwhelmingly cyclonic.They have not been explained.Under light winds favorable to visualization, linear surface features with

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Quantum thermodynamically consistent local master equations

Local master equations are a widespread tool to model open quantum systems, especially in the context of many-body systems.These equations, however, are believed to lead to thermodynamic anomalies and violation of the laws of thermodynamics.In contrast, here we rigorously prove that local master equations are consistent Spark Plugs with thermodynam

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Cytokinesis in vertebrate cells initiates by contraction of an equatorial actomyosin network composed of randomly oriented filaments

The actomyosin ring generates force to ingress the cytokinetic cleavage furrow in animal cells, yet its filament organization and the mechanism of contractility is not well understood.We quantified actin filament order in human cells using fluorescence polarization microscopy and found that cleavage furrow ingression initiates by contraction of an

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